Article Medicine, General & Internal
Comparative Study of Dental Custom CAD-CAM Implant Abutments and Dental Implant Stock Abutments
Daniel Adrian Tartea, Mihaela Ionescu, Horia Octavian Manolea, Veronica Mercut, Eugenia Obadan, Marina Olimpia Amarascu, Petre Costin Marasescu, Luminita Daguci, Sanda Mihaela Popescu
Summary: The implementation of CAD-CAM systems in dentistry has had a significant impact on the development of dental implantology and implant-supported prosthetics. This paper presents a comparative study between custom CAD-CAM implant abutments and dental implant stock abutments, revealing significant differences in dimensions and angles. The use of custom abutments results in improved aesthetics, retention, and reduced risk of screw loosening or fracturing.
JOURNAL OF CLINICAL MEDICINE (2023)
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Article Dentistry, Oral Surgery & Medicine
Use of intraoral scan for implant-supported dental prosthesis to design and fabricate a CAD -CAM veri fi cation device: A dental technique
Fang-Yu Su, Jen-Chih Tsai, Dean Morton, Wei-Shao Lin
Summary: This report describes a digital process for designing and fabricating a verification device for nonsegmental implant-supported dental prostheses directly from an intraoral scan. Using open source computer-aided design software, this technique offers an economical option for dentists and dental laboratory technicians to create a CAD-CAM verification device, particularly useful for cases with multiple scan bodies and large edentulous spaces.
JOURNAL OF PROSTHETIC DENTISTRY (2021)
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Article Dentistry, Oral Surgery & Medicine
Accuracy of 3D printed models and implant-analog positions according to the implant-analog-holder offset, inner structure, and printing layer thickness: an in-vitro study
Gan Jin, Seung-Ho Shin, June -Sung Shim, Keun-Woo Lee, Jong-Eun Kim
Summary: This study aimed to investigate the effects of implant-analog-holder (IAH) offset, inner structure, and printing layer thickness on the accuracy and positional changes of 3D printed dental models. The results showed that these factors significantly affected the accuracy of the printed models and the positions of the implant analogs. Clinicians can improve printing accuracy and minimize positional changes by considering the recommended IAH offset, inner structure, and printing layer thickness.
JOURNAL OF DENTISTRY (2022)
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Article Dentistry, Oral Surgery & Medicine
Fabricating a chairside CAD-CAM radiographic and surgical guide for dental implants: A dental technique
Nicholas B. DuVall
Summary: The new method for diagnosing and treatment planning implant-supported restorations utilizes an intraoral scanner and milling unit to create personalized radiographic and surgical guides.
JOURNAL OF PROSTHETIC DENTISTRY (2021)
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Article Dentistry, Oral Surgery & Medicine
CAD-CAM milled complete dentures with custom disks and prefabricated artificial teeth: A dental technique
Yumika Soeda, Manabu Kanazawa, Toshio Arakida, Maiko Iwaki, Shunsuke Minakuchi
Summary: A digital complete denture is manufactured using a customized disk made of resin with prefabricated artificial teeth. This technique provides dentures with a strong bond between the artificial teeth and the denture base, excellent esthetics due to the prefabricated teeth, and accurate occlusion with the custom occlusal surface.
JOURNAL OF PROSTHETIC DENTISTRY (2022)
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Article Chemistry, Physical
Effects of Implant-Abutment Connection Type and Inter-Implant Distance on Inter-Implant Bone Stress and Microgap: Three-Dimensional Finite Element Analysis
Takashi Matsuoka, Tamaki Nakano, Satoshi Yamaguchi, Shinji Ono, Shota Watanabe, Takumi Sato, Hirofumi Yatani
Summary: This study investigated the mechanical influences of the implant-abutment connection type and inter-implant distance on the inter-implant bone using three-dimensional finite element analysis. The results showed that a CC implant is advantageous for maintenance of the inter-implant bone, and regardless of the connection type, the stress of the inter-implant bone increases as the inter-implant distance decreases.
MATERIALS (2021)
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Article Dentistry, Oral Surgery & Medicine
Mechanical stability of fully personalized, abutment-free zirconia implant crowns on a novel implant-crown interface
Jenni Hjerppe, Ronald E. Jung, Christoph H. F. Hammerle, Mutlu Ozcan, Sven Muhlemann
Summary: This study aimed to test the failure load and failure mode of a novel implant-crown interface for personalized zirconia CAD-CAM crowns. Results showed that the new interface exhibited similar failure loads as conventional interfaces, but with different failure modes. The study has important clinical significance, as it simplifies the digital workflow for ceramic implant reconstructions.
JOURNAL OF DENTISTRY (2022)
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Article Biotechnology & Applied Microbiology
Digital Workflow for the Design, Manufacture, and Application of Custom-Made Short Implants With Wing Retention Device
Zexian Xu, Zhen Yang, Jianjun Yang
Summary: This article introduces a custom-made short implant with a wing retention structure and describes a precise and minimally invasive dental implant restoration scheme with digital technology in response to the challenge of severe deficiency of vertical bone height in the posterior maxillary region.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)
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Article Chemistry, Multidisciplinary
Primary Reconstruction of Total Maxillectomy with Custom-Made Subperiosteal Implant and Temporal Muscle Flap: A Case Report
Giacomo De Riu, Damiano Soma, Andrea Biglio, Maria Teresa Raho, Danilo Mura, Fabio Michelon, Giovanni Salzano, Pasquale Piombino, Jerome R. Lechien, Luigi Angelo Vaira
Summary: Accurately fitted subperiosteal bone flaps can be a safe and effective solution for primary maxillary reconstructions in patients who cannot undergo free bone flap reconstructions. This type of custom-made implant provides support to the soft tissues of the middle-third of the face and a solid anchorage for dental prostheses or palatal obturators, improving the quality of life for patients.
APPLIED SCIENCES-BASEL (2023)
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Article Dentistry, Oral Surgery & Medicine
Fabrication of a CAD-CAM custom healing abutment guided by a conventional dental radiograph for delayed loaded dental implants: A dental technique
Islam M. Abdel Raheem, Ihab A. Hammad, Sanaa H. Abel Kader, Rania A. Fahmy
Summary: This article describes a technique for fabricating a custom healing abutment using CAD-CAM technology from a PMMA material. The dimensions of the abutment are measured from dental radiographs and diagnostic casts. The healing abutment is used to guide soft tissue healing and inform the design of the customized implant abutment.
JOURNAL OF PROSTHETIC DENTISTRY (2022)
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Article Health Care Sciences & Services
Computer-Aided Design/Computer-Aided Manufacturing of Customized Abutment for Rehabilitating a Malpositioned Implant Using Digital Flow: A Case Report
Jose Henrique Lopo Barros, Murilo Navarro de Oliveira, Igor Oliveiros Cardoso, Guilherme Jose Pimentel Lopes de Oliveira, Celio Jesus do Prado, Flavio Domingues Das Neves
Summary: This study presents a rehabilitation option for malpositioned implants using intraoral scanning and CAD/CAM technology to produce customized abutments. This method can effectively improve the clinical outcome of malpositioned implants, while reducing costs and patient morbidity.
HEALTHCARE (2023)
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Article Chemistry, Multidisciplinary
Evaluation of the Trueness of Digital Implant Impressions According to the Implant Scan Body Orientation and Scanning Method
Bora Lee, Na-Eun Nam, Seung-Ho Shin, Jung-Hwa Lim, June-Sung Shim, Jong-Eun Kim
Summary: The study presents a strategy for operators to obtain more accurate digital impressions in single implant cases by focusing on the orientation of the scan body and scanning method. It was found that connecting the scan body with the flat surface facing the buccal direction and scanning all areas leads to higher accuracy in digital impressions, especially when using a tabletop scanner.
APPLIED SCIENCES-BASEL (2021)
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Article Dentistry, Oral Surgery & Medicine
Effect of abutment finish lines on the mechanical behavior and marginal fit of screw-retained implant crowns: An in vitro study
Marta Garcia-Gonzalez, Ignacio Gonzalez-Gonzalez, Ismael Garcia-Garcia, Sergio Blason-Gonzalez, Maria Jesus Lamela-Rey, Alfonso Fernandez-Canteli, Angel Alvarez-Arenal
Summary: Patient stories provide important information for doctors and translators to better understand the patient's needs and situation.
JOURNAL OF PROSTHETIC DENTISTRY (2022)
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Article Multidisciplinary Sciences
Efficacy of a newly designed angulation-adjustable film holder for reducing cone-cutting errors and saving time in horizontal tube-shift technique by dental students
Peraya Puapichartdumrong, Nongnapat Eakpunyakul, Suphakarn Tanpumiprathet, Pimrekha Khueankaew, Priawwan Saelim, Thosapol Piyapattamin
Summary: This study compared the cone-cutting error frequency and X-ray cone alignment time between the angulation-adjustable and XCP holders in the horizontal tube-shift technique. It found that the angulation-adjustable holder resulted in fewer cone-cutting errors and shorter X-ray cone alignment time compared to the XCP instrument. This has important clinical implications for enhancing patient care and reducing treatment time.
HELIYON (2022)
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Article Dentistry, Oral Surgery & Medicine
RESEARCH AND EDUCATION Comparison of strength of milled and conventionally processed PMMA complete-arch implant-supported immediate interim fixed dental prostheses
Konstantina Angelara, Manuel Bratos, John A. Sorensen
Summary: The purpose of this study was to measure the flexural strength and failure load of acrylic resin immediate implant-supported interim prostheses fabricated by conventional processing and computer-aided manufacturing. The results showed that implant fixed interim structures milled from high-density PMMA blanks had a 35% higher flexural strength than heat-processed denture base PMMA. The low-profile coping design was stronger than the heat-processed material, and the failure point was relocated from the lateral walls to the cervical margin area.
JOURNAL OF PROSTHETIC DENTISTRY (2023)
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Article Dentistry, Oral Surgery & Medicine
Preliminary application and evaluation of digital step-by-step tooth-preparation templates
Shimin Wang, Weiwei Zhao, Hongqiang Ye, Yunsong Liu, Yongsheng Zhou
Summary: This study aimed to evaluate the application of new digitally designed step-by-step templates to guide tooth preparation. The results showed that using the template significantly improved the efficiency and quality of tooth preparation for inexperienced dentists.
JOURNAL OF PROSTHETIC DENTISTRY (2023)
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Article Biology
The accuracy of a novel 3D digital evaluation method of intraoral fitness for removable partial dentures
Jung-min Yoon, Yunsong Liu, Yushu Liu, Yuchun Sun, Hongqiang Ye, Yongsheng Zhou
Summary: This study introduced a novel 3D digital evaluation method for assessing the intraoral fitness of removable partial dentures (RPDs), showing that 3D analysis on duplicated polyether cast has comparable accuracy to 3D analysis on the stone cast for evaluating clinical fitness of RPDs.
COMPUTERS IN BIOLOGY AND MEDICINE (2022)
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Article Dentistry, Oral Surgery & Medicine
The accuracies of three intraoral scanners with regard to shade determination: An in vitro study
Mingming Huang, Yong Wang, Yuchun Sun, Yongsheng Zhou, Yunsong Liu, Hongqiang Ye
Summary: This study compared the accuracies of three intraoral scanners for shade determination function and investigated their shade-matching characteristics. The results showed that all three scanners had good accuracy and reproducibility, with the T3 scanner performing the best.
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY (2023)
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Article Dentistry, Oral Surgery & Medicine
Comparison of the dimensional and morphological accuracy of three-dimensional digital dental casts digitized using different methods
Jiahui Ye, Shimin Wang, Zixuan Wang, Yunsong Liu, Yuchun Sun, Hongqiang Ye, Yongsheng Zhou
Summary: The purpose of this study was to compare the accuracy of different scanning methods for digital dental casts. The results showed that plaster cast scanning and impression scanning methods had better dimensional accuracy compared to intraoral scanning and cone-beam computed tomography scanning methods. However, intraoral scanning method still satisfied the clinical requirements for fixed restorations in small units.
ODONTOLOGY (2023)
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Article Medicine, Research & Experimental
D-Mannose prevents bone loss under weightlessness
Ranli Gu, Hao Liu, Menglong Hu, Yuan Zhu, Xuenan Liu, Feilong Wang, Likun Wu, Danyang Song, Yunsong Liu
Summary: This study found that D-mannose can protect rats from bone loss and urinary tract infections under weightlessness. The bone protective effects of D-mannose are mediated by inhibiting osteoclast cell fusion.
JOURNAL OF TRANSLATIONAL MEDICINE (2023)
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Article Chemistry, Multidisciplinary
Apoptotic Vesicles Regulate Bone Metabolism via the miR1324/SNX14/SMAD1/5 Signaling Axis
Yuan Zhu, Kunkun Yang, Yawen Cheng, Yaoshan Liu, Ranli Gu, Xuenan Liu, Hao Liu, Xiao Zhang, Yunsong Liu
Summary: This study investigates the role of apoptotic vesicles (apoVs) derived from human bone marrow mesenchymal stem cells (hBMMSCs) in bone metabolism and the molecular mechanism of the observed effects. The results show that apoVs can promote osteogenesis and inhibit osteoclast formation in vitro and in vivo. The mechanisms responsible for apoV-induced bone regeneration include the release of miR1324, which inhibits expression of the target gene Sorting Nexin 14 (SNX14) and thus activates the SMAD1/5 pathway in target cells.
SMALL (2023)
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Article Biochemistry & Molecular Biology
ZIM1 Combined with Hydrogel Inhibits Senescence of Primary PαS Cells during In Vitro Expansion
Yueming Tian, Menglong Hu, Xuenan Liu, Xu Wang, Dazhuang Lu, Zheng Li, Yunsong Liu, Ping Zhang, Yongsheng Zhou
Summary: Bone marrow stem cells (BMSCs) are potential seed cells for bone tissue engineering, but cell senescence could affect their therapeutic effects. This study aimed to explore the transcriptomic differences between uncultured and passaged BMSCs and identify a practical anti-aging target gene. Through flow cytometry analysis, PDGFR-alpha(+)SCA-1(+)CD45(-)TER119(-) cells were sorted as BMSCs. Various cellular senescence phenotypes and associated transcriptional alterations during different cell culture processes were studied. Imprinted zinc-finger gene 1 (Zim1) was found to play a critical role in anti-aging, and its combination with Gelatin methacryloyl (GelMA) reduced senescence markers and increased telomerase activity. The combined application of Zim1 and hydrogel showed potential for inhibiting the senescence of BMSCs during in vitro expansion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
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Article Biochemistry & Molecular Biology
Integrative Analysis Reveals the Diverse Effects of 3D Stiffness upon Stem Cell Fate
Muxin Yue, Yunsong Liu, Ping Zhang, Zheng Li, Yongsheng Zhou
Summary: The study investigates the interaction between stem cell transcriptional and metabolic signals in extracellular matrices with different stiffnesses. It reveals that the stiffness of the matrix plays a role in determining the fate of bone marrow mesenchymal stem cells, with different stiffnesses leading to different differentiation pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
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Article Cell & Tissue Engineering
Organoid Culture Development for Skeletal Systems
Jia Qing, Qian Guo, Longwei Lv, Xiao Zhang, Yunsong Liu, Boon Chin Heng, Zheng Li, Ping Zhang, Yongsheng Zhou
Summary: Organoids are ideal in vitro models widely used in various fields, such as regenerative medicine, disease research, and drug screening. The complexity of bone tissue and heterogeneity of osteogenic stem/progenitor cells pose challenges in constructing organoids for modeling skeletal systems. This study examines current progress in skeletal system organoid culture systems and provides cues for future research in this field by analyzing the current research status of skeletal stem cells, their microenvironmental factors, and potential organoid culture matrix candidates.
TISSUE ENGINEERING PART B-REVIEWS (2023)
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Review Engineering, Biomedical
The biological functions of europium-containing biomaterials: A systematic review
Likun Wu, Fan Yang, Yijia Xue, Ranli Gu, Hao Liu, Dandan Xia, Yunsong Liu
Summary: The biological functions of rare-earth elements (REEs) have been investigated, and recent studies have shown that doping or alloying some REEs can improve the properties of traditional biomaterials. Europium (Eu), a low-toxicity and biocompatible REE, shows promise in biomedicine. This article systematically reviews the osteogenic, angiogenic, neuritogenic, antibacterial, and anti-tumor properties of Eu-containing biomaterials, providing insights for their biomedical applications. Data collection for this review was completed in October 2022, and 30 relevant articles were included. Most articles suggest that doping Eu ions or Eu-compound nanoparticles can enhance the osteogenic, angiogenic, neuritogenic, antibacterial, and anti-tumor properties of biomaterials. The angiogenic, antibacterial, and potential neuritogenic effects of Eu(OH)3 nanoparticles have also been demonstrated.
MATERIALS TODAY BIO (2023)
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Review Engineering, Biomedical
Surface modification of titanium implants with Mg-containing coatings to promote osseointegration
Siyi Wang, Xiao Zhao, Yuchien Hsu, Yunjiao He, Feilong Wang, Fan Yang, Fanyu Yan, Dandan Xia, Yunsong Liu
Summary: Titanium and titanium alloys are commonly used in dental implants, but their inert surface leads to delayed osseointegration. Magnesium ions, known for promoting bone regeneration, have been extensively studied for surface modification of titanium implants. This systematic review summarizes the methods, effects, and clinical applications of magnesium-containing coatings for titanium implant surface modification.
ACTA BIOMATERIALIA (2023)
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Article Cell & Tissue Engineering
Alkaline shear-thinning micro-nanocomposite hydrogels initiate endogenous TGFβ signaling for in situ bone regeneration
Yuting Niu, Zhen Yang, Yang Yang, Xu Wang, Ping Zhang, Longwei Lv, Sainan Wang, Yan Liu, Yunsong Liu, Yongsheng Zhou
Summary: Recruiting endogenous stem cells and activating TGF beta 1 can lead to in situ bone regeneration without stem cell transplantation. A newly developed alkaline shear-thinning micro-nanocomposite hydrogel showed excellent biocompatibility and biodegradability, and promoted cell proliferation, osteogenic differentiation, and bone formation in a rat bone defect model.
NPJ REGENERATIVE MEDICINE (2023)
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Article Biochemistry & Molecular Biology
BHLHE40 Maintains the Stemness of P alpha S Cells In Vitro by Targeting Zbp1 through the Wnt/beta-Catenin Signaling Pathway
Menglong Hu, Yueming Tian, Xuenan Liu, Qian Guo, Dazhuang Lu, Xu Wang, Longwei Lv, Xiao Zhang, Yunsong Liu, Yongsheng Zhou, Ping Zhang
Summary: In this study, we investigated the premium culture conditions for P alpha S cells, representative of bone mesenchymal stem cells (BMSCs). It was found that the stemness of P alpha S cells gradually decreased during in vitro expansion and that BHLHE40 played a critical role in maintaining the stemness of P alpha S cells.
BIOMEDICINES (2023)
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Review Engineering, Biomedical
CeO2 Nanoparticles to Promote Wound Healing: A Systematic Review
Yijia Xue, Fan Yang, Likun Wu, Dandan Xia, Yunsong Liu
Summary: Cerium oxide nanoparticles, with their antioxidant and antibacterial properties, have been widely used in wound healing materials. This article systematically reviews the progress made in the study of various forms of cerium oxide nanoparticles over the past decade, with a focus on the relationship between concentration and effectiveness. It is expected that cerium oxide nanoparticles will play an important role in dressings that require antibacterial, antioxidant, and wound healing promoting properties.
ADVANCED HEALTHCARE MATERIALS (2023)
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