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, Caroline Dutil Healthy Active Living and Obesity Research Group, Children’s Hospital of Eastern Ontario (CHEO) Research Institute , Ottawa, ON , School of Human Kinetics, University of Ottawa , Ottawa, ON , Canada Search for other works by this author on: Oxford Academic Irina Podinic Healthy Active Living and Obesity Research Group, Children’s Hospital of Eastern Ontario (CHEO) Research Institute , Ottawa, ON , Canada Search for other works by this author on: Oxford Academic Ryan B Featherstone Healthy Active Living and Obesity Research Group, Children’s Hospital of Eastern Ontario (CHEO) Research Institute , Ottawa, ON , Canada School of Human Kinetics, University of Ottawa , Ottawa, ON , Canada Centre for Healthy Active Living (CHAL), Children’s Hospital of Eastern Ontario (CHEO) , Ottawa, ON , Canada Search for other works by this author on: Oxford Academic Amelia Eaton Healthy Active Living and Obesity Research Group, Children’s Hospital of Eastern Ontario (CHEO) Research Institute , Ottawa, ON , Canada School of Human Kinetics, University of Ottawa , Ottawa, ON , Canada Search for other works by this author on: Oxford Academic Christin M Sadler Healthy Active Living and Obesity Research Group, Children’s Hospital of Eastern Ontario (CHEO) Research Institute , Ottawa, ON , Canada School of Human Kinetics, University of Ottawa , Ottawa, ON , Canada Search for other works by this author on: Oxford Academic Gary S Goldfield Healthy Active Living and Obesity Research Group, Children’s Hospital of Eastern Ontario (CHEO) Research Institute , Ottawa, ON , Canada Department of Pediatrics, University of Ottawa , Ottawa, ON , Canada Search for other works by this author on: Oxford Academic Stasia Hadjiyannakis Centre for Healthy Active Living (CHAL), Children’s Hospital of Eastern Ontario (CHEO) , Ottawa, ON , Canada Department of Pediatrics, University of Ottawa , Ottawa, ON , Canada Search for other works by this author on: Oxford Academic Reut Gruber Department of Psychiatry, McGill University , Montreal, QC , Canada Attention, Behaviour and Sleep Lab, Douglas Mental Health University Institute , Montreal, QC , Canada Search for other works by this author on: Oxford Academic Mark S Tremblay Healthy Active Living and Obesity Research Group, Children’s Hospital of Eastern Ontario (CHEO) Research Institute , Ottawa, ON , Canada Department of Pediatrics, University of Ottawa , Ottawa, ON , Canada Search for other works by this author on: Oxford Academic Denis Prud’homme School of Human Kinetics, University of Ottawa , Ottawa, ON , Canada Université de Moncton , Moncton, NB , Canada Search for other works by this author on: Oxford Academic
Jean-Philippe Chaput Healthy Active Living and Obesity Research Group, Children’s Hospital of Eastern Ontario (CHEO) Research Institute , Ottawa, ON , Canada School of Human Kinetics, University of Ottawa , Ottawa, ON , Canada School of Epidemiology and Public Health, University of Ottawa , Ottawa, ON , Canada Department of Pediatrics, University of Ottawa , Ottawa, ON , Canada Corresponding author. Jean-Philippe Chaput, Healthy Active Living and Obesity Research Group, Children’s Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON, Canada, K1H 8L1. Email: jpchaput@cheo.on.ca. Search for other works by this author on: Oxford Academic
https://orcid.org/0000-0002-5607-5736 Sleep, Volume 47, Issue 5, May 2024, zsad313, https://doi.org/10.1093/sleep/zsad313
Published:
09 December 2023
Article history
Received:
13 June 2023
Revision received:
01 November 2023
Published:
09 December 2023
Corrected and typeset:
23 December 2023
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Caroline Dutil, Irina Podinic, Ryan B Featherstone, Amelia Eaton, Christin M Sadler, Gary S Goldfield, Stasia Hadjiyannakis, Reut Gruber, Mark S Tremblay, Denis Prud’homme, Jean-Philippe Chaput, Sleep and insulin sensitivity in adolescents at risk of type 2 diabetes: the Sleep Manipulation in Adolescents at Risk of Type 2 Diabetes randomized crossover study, Sleep, Volume 47, Issue 5, May 2024, zsad313, https://doi.org/10.1093/sleep/zsad313
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Abstract
Study Objectives
To investigate the effect of increasing sleep duration for 1 week, compared to a week of habitual and decreased sleep, on insulin sensitivity (IS) in adolescents at risk for type 2 diabetes (T2D).
Methods
Adolescents, 13–18 years old, at risk for T2D, with obesity and other risk factors, were recruited for a randomized (1:1), open-label, sex-stratified crossover study, that manipulated time-in-bed to modify sleep duration (measured by actigraphy). Following a week of habitual (HB) sleep, time-in-bed was increased (IN) and decreased (DE) by 1 hour 30 min/night for 1 week, counterbalanced across participants (HBINDE or HBDEIN), and separated by a week of washout sleep. The main outcome measure was IS, obtained via 2-hour oral-glucose-tolerance-test conducted after each sleep week.
Results
Of the 43 participants recruited, 36 (84%) completed all sleep interventions (52.8% female, age = 15.1 years, body mass index = 99.9th percentile, order: HBINDE = 18 and HBDEIN = 18). On average, during the HB week, participants slept 7 hours 31 min/night; sleep duration was 1 hour 02 min/night higher during the IN week and 1 hour 19 min/night lower during the DE week. We found a significant effect of sleep week on IS with a large effect size. Following the IN sleep week, IS was 20% higher compared to after the HB and DE sleep weeks, but there was no significant difference in IS following HB versus DE sleep weeks.
Conclusions
Whenever possible, clinicians should empower youth at risk of T2D to improve their sleep duration, since even a modest increase in sleep duration of 1 h/night for 1 week can have a positive impact on IS in this population.
Clinical Trials
Sleep Extension and IS in Adolescents, https://clinicaltrials.gov/study/NCT03754036, November 23rd, 2018.
Trial registration
ClinicalTrials.gov (ID:NCT03754036).
Graphical Abstract
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adolescents, experimental study, insulin resistance, insulin sensitivity, obesity, sleep duration, sleep manipulation, type 2 diabetes
© The Author(s) 2023. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
Topic:
- obesity
- diabetes mellitus, type 2
- adolescent
- sleep
- insulin sensitivity
- sleep duration
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